A new spirocyclic cycloartane triterpenoid from Souliea vaginata.
10.19540/j.cnki.cjcmm.20190619.202
- Author:
Si-Yan ZHANG
1
;
Zhu-Jun FANG
1
;
Yan-Lan WANG
1
;
Chang-Xin ZHOU
1
;
Jian-Xia MO
1
;
Li-She GAN
1
Author Information
1. Institute of Modern Chinese Medicine,College of Pharmaceutical Sciences,Zhejiang University Hangzhou 310058,China.
- Publication Type:Journal Article
- Keywords:
Souliea vaginata;
chemical constituents;
cycloartane triterpenoids
- MeSH:
Actaea/metabolism*;
Glycosides;
Lipopolysaccharides;
Molecular Structure;
Triterpenes/metabolism*
- From:
China Journal of Chinese Materia Medica
2019;44(20):4476-4480
- CountryChina
- Language:Chinese
-
Abstract:
The 70% ethanol extract of the whole plant of Souliea vaginata was purified by multi-chromatographic methods including macroporous resin,silica gel,Sephadex LH-20,and C18-reversed-phase column chromatography. A new spirocyclic cycloartane triterpenoid was isolated and identified as( 16 R*,20 R*,23 S*,24 R*,25 S*)-16,23: 23,26-diepoxy-15α,24,25-trihydroxy-9,19-cycloart-3β-O-β-D-xylopyranoside( 1),and named as soulieoside S. Its planar structure and relative configuration were determined by spectroscopic techniques including 2 D NMR and HRESI-MS. As one of the main components of S. vaginata,compound 1 was evaluated for its anti-inflammatory activity by a lipopolysaccharide( LPS)-stimulated NO production model in RAW264. 7 macrophages,but it didn't show NO production inhibitory effect.
