Overview and prospects of traditional Chinese medicine blending technology oriented by quality consistency.
10.19540/j.cnki.cjcmm.20190901.302
- Author:
Xiao-Rong XU
1
;
Ting ZHANG
1
;
Pan LI
1
;
Qiang XU
2
;
Bi FENG
1
;
Peng TAN
3
;
Jun-Han CAO
3
;
Run-Chun XU
1
;
Ding-Kun ZHANG
1
;
Li HAN
1
Author Information
1. State Key Labaratory of Characteristic Chinese Medicine Resources in Southwest China,Development and Utilization of Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
2. Medical Information Engineering College,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
3. Chengdu Institute of Food and Drug Control Chengdu 610045,China.
- Publication Type:Review
- Keywords:
algorithm principles;
artificial intelligence;
blending technology;
quality consistency;
traditional Chinese medicine
- MeSH:
Algorithms;
Drug Industry;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Reproducibility of Results;
Technology
- From:
China Journal of Chinese Materia Medica
2019;44(22):4786-4792
- CountryChina
- Language:Chinese
-
Abstract:
The consistency of drug quality is related to the clinical efficacy and safety,which is highly valued by the government and relevant industries. Compared with chemical medicine,traditional Chinese medicine originates from the nature,and is greatly influenced by natural factors,such as the place of origin,cultivation and processing technology,climate. The quality consistency of traditional Chinese medicine is poor. The quality consistency has become the pain point and difficulty of the development of the traditional Chinese medicine industry,which seriously affects the stability and controllability of clinical efficacy and the reproducibility or recognition of modern research results. It is also a bottleneck for Chinese patent medicine to enter the international market. Mixed batch blending technology is an effective method for the scientific guarantee of the quality consistency in other industries and disciplines,and widely applied in liquor making industry,tobacco industry and perfume industry. Overseas,mixed batch blending technology has been successfully applied in guaranteeing the quality consistency of Ginkgo biloba preparations Jinnado. It has been used in the production of Chinese formulations in Japan for more than 30 years. In recent years,mixed batch blending technology has been introduced into the pharmaceutical field to ensure the quality consistency of traditional Chinese medicine,and relevant research has gradually increased.This manuscript reviews the application of blending technology in other disciplines,summarizes the algorithm principles and software systems of mixed batch blending in traditional Chinese medicine or natural medicine,explains the specific implementation process of mixed batch blending technology,and looks forward to the application prospects of artificial intelligence and other new technologies,in the hope of providing new ideas and technologies for breaking through the problem of quality consistency,and boosting the high-quality and high-level development of Chinese medicine industry in the new era.
