Research Progress in the Regulation of Follicle Development by Melatonin.
10.3881/j.issn.1000-503X.15473
- Author:
Jing-Jing LIU
1
;
Zong-Yang LI
2
;
Li-Mei LIU
1
;
Xiao-Yan PAN
2
Author Information
1. School of Medical Technology,Beihua University,Jilin,Jilin 132013,China.
2. Center for Reproductive Medicine,Jilin Medical University,Jilin,Jilin 132013,China.
- Publication Type:Journal Article
- Keywords:
follicle development;
granulosa cells;
melatonin;
oocyte;
oxidative stress
- MeSH:
Animals;
Female;
Melatonin/pharmacology*;
Ovarian Follicle;
Oocytes;
Granulosa Cells/physiology*;
Mammals
- From:
Acta Academiae Medicinae Sinicae
2023;45(6):997-1004
- CountryChina
- Language:Chinese
-
Abstract:
Melatonin,an endocrine hormone synthesized by the pineal gland,plays an important role in the reproduction.The growth and development of follicles is the basis of female mammalian fertility.Follicles have a high concentration of melatonin.Melatonin receptors exist on ovarian granulosa cells,follicle cells,and oocytes.It regulates the growth and development of these cells and the maturation and atresia of follicles,affecting female fertility.This paper reviews the protective effects and regulatory mechanisms of melatonin on the development of ovarian follicles,granulosa cells,and oocytes and makes an outlook on the therapeutic potential of melatonin for ovarian injury,underpinning the clinical application of melatonin in the future.
