Research Progress in Exosomes in the Pathogenesis of Bronchial Asthma.
10.3881/j.issn.1000-503X.15330
- Author:
Li-Li HUANG
1
;
Jun WANG
2
Author Information
1. Department of Medicine,Graduate School of Nanchang University,Nanchang 330006,China.
2. The Second Department of Respiratory Disease,Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College),Nanchang 330006,China.
- Publication Type:Journal Article
- Keywords:
asthma;
exosomes;
immune effector cells;
structural cells of the lung
- MeSH:
Humans;
Exosomes/pathology*;
Asthma;
Lung/pathology*;
Inflammation;
Chronic Disease
- From:
Acta Academiae Medicinae Sinicae
2023;45(5):827-832
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a heterogeneous chronic inflammatory disease involving multiple immune cells and structural cells.It is characterized by airflow limitation,airway hyperresponsiveness,and airway remodeling,with complex pathogenesis.In recent years,the research on exosomes has developed rapidly.Exosomes are small vesicles secreted by a variety of cells and are naturally found in various biological fluids,with stability and biocompatibility.Exosomes from different cells are involved in pathophysiological processes such as airway inflammation,remodeling,and hyperresponsiveness through specific mechanisms and play a regulatory role in multiple links in bronchial asthma.This review focuses on the role of exosomes from different cells in the pathogenesis of bronchial asthma.
