Comparison on Performance of Quantitative Ultrasound and Dual-Energy X-ray Absorptiometry in Evaluating Bone Health of Adults Aged 18-40 Years.
10.3881/j.issn.1000-503X.15695
- Author:
Yu-Xian KUANG
1
;
Hong CHENG
2
;
Yi-Ying ZHENG
1
;
Wei-Ye CHEN
1
;
Zhen-Xin MA
1
;
Gao-Yong ZOU
1
;
Ding ZENG
1
;
Jie MI
3
;
Li LIU
1
Author Information
1. Department of Epidemiology and Health Statistics,School of Public Health,Guangdong Pharmaceutical University,Guangzhou 510310,China.
2. Department of Epidemiology,Capital Institute of Pediatrics,Beijing 100020,China.
3. Center for Non-Communicable Disease Management,Beijing Children's Hospital,Capital Medical University, National Center for Children's Health,Beijing 100045,China.
- Publication Type:Journal Article
- Keywords:
bone mineral density;
dual-energy X-ray absorptiometry;
low bone mass;
quantitative ultrasound;
speed of sound
- MeSH:
Male;
Female;
Adult;
Humans;
Absorptiometry, Photon/methods*;
Bone Density;
Ultrasonography;
Bone and Bones;
ROC Curve;
Sensitivity and Specificity
- From:
Acta Academiae Medicinae Sinicae
2023;45(5):737-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the consistency of quantitative ultrasound(QUS)and dual-energy X-ray absorptiometry(DXA)in measuring bone mineral density(BMD)of adults aged 18-40 years in Guangzhou and evaluate the diagnostic value of QUS for identifying low bone mass.Methods DXA was employed to measure the BMD and QUS to measure the speed of sound(SOS)in 731 participants.The Bland-Altman analysis was performed to evaluate the consistency of Z scores between SOS and BMD.With the BMD Z ≤-2.00 as the diagnostic criterion for low bone mass,the receiver operating characteristics curve of QUS was established,and the area under the curve(AUC)and the sensitivity,specificity,and correct diagnostic index for the optimal cut-off of SOS Z score were calculated.Results The results of Bland-Altman analysis showed that the mean differences in the Z scores of SOS and BMD in males and females were 1.27(-0.94 to 3.47)and 0.93(-1.33 to 3.18),respectively.The AUC of SOS Z score in the diagnosis of low bone mass in males and females was 0.734(95%CI=0.380-0.788)and 0.679(95%CI=0.625-0.732),respectively.In males,the optimal cut-off of SOS Z score for low bone mass was -0.35,with the sensitivity,specificity,and correct diagnostic index of 64.1%,68.6%,and 0.327,respectively.In females,the optimal cut-off value of SOS Z scores for low bone mass was -1.14,with the sensitivity,specificity,and correct index of 73.9%,54.8%,and 0.285,respectively.Conclusion QUS and DXA show poor consistency in the diagnosis of BMD in the adults aged 18-40 years in Guangzhou,while QUS demonstrates an acceptable value in identifying low bone mass.
