Ferroptosis:Mechanism and Role in Malignant Tumors.
10.3881/j.issn.1000-503X.15379
- Author:
Xin-Feng WANG
1
;
Yu-Xin YAO
1
;
Pan WANG
1
Author Information
1. Department of Thoracic Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,CAMS and PUMC,Beijing 100021,China.
- Publication Type:Journal Article
- Keywords:
antioxidant mechanism;
ferroptosis;
iron accumulation;
lipid peroxidation;
malignant tumor
- MeSH:
Humans;
Ferroptosis;
Antioxidants;
Apoptosis;
Neoplasms;
Autophagy
- From:
Acta Academiae Medicinae Sinicae
2023;45(4):647-654
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of programmed cell death different from other cell death pathways such as apoptosis,autophagy,necrosis,and pyroptosis in terms of initiation,mechanisms,and molecular characteristics.As the accumulation of phospholipid hydroperoxides is the hallmark of ferroptosis,the balance between oxidative damage and antioxidant defense is critical to the regulatory mechanism of ferroptosis.In cancer,the upregulation of antioxidant defense pathways can inhibit ferroptosis,thereby promoting cancer cells to survive the oxidative stress and develop drug resistance.This review systematically introduces the main features and regulatory mechanisms of ferroptosis.In addition,we summarize the role of ferroptosis in the progression and drug resistance of malignant tumors,providing novel implications for further research on the pathogenesis of malignant tumors and discovery of new targets for anti-cancer therapy.
