Expression of Cyclooxygenase-2 in Patients With Snow-White Sign of Advanced Colorectal Adenomas.
10.3881/j.issn.1000-503X.15465
- Author:
Jian-Li GAO
1
;
Xue-Hong WANG
2
;
Zhen-Qi MA
2
;
Sheng-Sen YANG
2
;
Hong-Bin SHI
1
Author Information
1. Graduate School of Qinghai University,Xining 810016,China.
2. Department of Gastroenterology,Affiliated Hospital of Qinghai University,Xining 810000,China.
- Publication Type:Journal Article
- Keywords:
advanced adenomas;
chicken skin-like mucosa;
colorectal tumor;
cyclooxygenase-2 protein;
snow-white sign
- MeSH:
Adult;
Humans;
Cyclooxygenase 2;
Snow;
Colorectal Neoplasms;
Adenoma
- From:
Acta Academiae Medicinae Sinicae
2023;45(4):591-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of cyclooxygenase-2 (COX-2) in the patients with snow-white sign of advanced colorectal adenoma (ACA) and explore its clinical significance.Method Western blotting was employed to determine the expression of COX-2 in the adenoma tissue and the normal tissue adjacent to the adenoma tissue (>5 cm away from the distal end of the adenoma tissue) of 40 ACA patients with snow-white sign and 40 ACA patients without snow-white sign.Results The appearance of snow-white sign in ACA patients was associated with patient age (P=0.001) and not associated with sex,smoking history,drinking history,ethnic groups,family history of colorectal cancer,abdominal pain,diarrhea,constipation,fecal occult blood,or tumor markers (all P>0.05).Snow-white sign mainly appeared in the ACA patients with multiple adenomas (P=0.004),large adenomas (P=0.006),adenomas in distal colon (P=0.015),protruding polyps (P=0.044),and late-stage pathology (P=0.010).The occurrence of snow-white sign showed no difference in the ACA patients with different results of Japan NBI Expert Team classification (P=0.502).The expression of COX-2 in the adenoma tissue was higher than that in the adjacent normal tissue in the patients with and without snow-white sign (P<0.001,P=0.004).The patients with snow-white sign had higher expression of COX-2 protein in the adenoma tissue than the patients without snow-white sign (P=0.001).The expression of COX-2 protein in the adjacent healthy tissue had no significant difference between the patients with and without snow-white sign (P=0.603).Conclusions Snow-white sign is more like to appear in the ACA patients with young age,multiple and large adenomas,adenomas in distal colon,protruding polyps,and late-stage pathology.Moreover,the expression of COX-2 in the ACA patients with snow-white sign is significantly higher than that in the ACA patients without snow-white sign.The adults with snow-white sign are prone to cancerization than those without snow-white sign.
