A Prediction Model for Human Immunodeficiency Virus Infection and Mother-to-Child Transmission Based on the Expression Levels of Selenoprotein Genes.
10.3881/j.issn.1000-503X.15569
- Author:
Yan QI
1
;
Rong-Qiang ZHANG
1
;
Ling-Zhi ZHANG
2
;
Jing LI
1
;
Xue-Qin CHEN
1
;
Guo-Tao FU
1
;
Ling-Lan LI
1
;
Xiu-Qin LI
3
Author Information
1. Department of Epidemiology and Health Statistics,School of Public Health,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China.
2. Department of Laboratory Medicine,The Second Hospital of Hanbin District,Ankang,Shaanxi 725021,China.
3. Department of Public Administration,School of Humanities and Management,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China.
- Publication Type:Journal Article
- Keywords:
Logistic regression;
human immunodeficiency virus;
mother-to-child transmission;
nomogram;
selenoprotein gene
- MeSH:
Humans;
Female;
HIV Infections;
Acquired Immunodeficiency Syndrome;
Infectious Disease Transmission, Vertical;
Nomograms;
Selenoproteins/genetics*
- From:
Acta Academiae Medicinae Sinicae
2023;45(4):563-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of selenoprotein genes in human immunodeficiency virus(HIV)infection and its mother-to-child transmission,so as to provide a theoretical basis for the prevention,diagnosis,and treatment of acquired immunodeficiency syndrome.Methods The dataset GSE4124 was downloaded from the Gene Expression Omnibus(GEO).Two groups of HIV-positive mothers(n=25)and HIV-negative mothers(n=20)were designed.HIV-positive mothers included a subset of transmitter(TR)mothers(n=11)and non-transmitter(NTR)mothers(n=14).Then,t-test was carried out to compare the expression levels of selenoprotein genes between the four groups(HIV-positive vs. HIV-negative,NTR vs. HIV-negative,TR vs. HIV-negative,TR vs. NTR).Univariate and multivariate Logistic regression were adopted to analyze the effects of differentially expressed genes on HIV infection and mother-to-child transmission.R software was used to establish a nomogram prediction model and evaluate the model performance.Results Compared with the HIV-negative group,HIV-positive,NTR,and TR groups had 8,5 and 8 down-regulated selenoprotein genes,respectively.Compared with the NTR group,the TR group had 4 down-regulated selenoprotein genes.Univariate Logistic regression analysis showed that abnormally high expression of GPX1,GPX3,GPX4,TXNRD1,TXNRD3,and SEPHS2 affected HIV infection and had no effect on mother-to-child transmission.The multivariate Logistic regression analysis showed that the abnormally high expression of TXNRD3(OR=0.032,95%CI=0.002-0.607,P=0.022)was positively correlated with HIV infection.As for the nomogram prediction model,the area under the receiver-operating characteristic curve for 1-year survival of HIV-infected patients was 0.840(95%CI=0.690-1.000),and that for 3-year survival of HIV-infected patients was 0.870(95%CI=0.730-1.000).Conclusions Multiple selenoprotein genes with down-regulated expression levels were involved in the regulation of HIV infection and mother-to-child transmission.The abnormal high expression of TXNRD3 was positively correlated with HIV infection.The findings provide new ideas for the prevention,diagnosis,and treatment of acquired immunodeficiency syndrome.
