Advances in the biosynthesis of cyclodipeptide type natural products derived from actinomycetes.

Yunhong Huang; Jinzu LI; Simin Chen; Wenhui Liu; Miaoer WU; Du Zhu; Yunchang Xie

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Advances in the biosynthesis of cyclodipeptide type natural products derived from actinomycetes.

Author: Yunhong HUANG ¹ ; Jinzu LI ¹ ; Simin CHEN ¹ ; Wenhui LIU ¹ ; Miaoer WU ¹ ; Du ZHU ¹ ; Yunchang XIE ¹
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1. Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi Province, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, Jiangxi, China.
Publication Type:Journal Article
Keywords: actinomycetes; cyclodipeptide; cyclodipeptide synthase (CDPS); nonribosomal peptide synthetase (NRPS); skeleton modification
MeSH: Actinobacteria/metabolism*; Actinomyces/metabolism*; Biological Products/metabolism*; Bacteria/metabolism*; Diketopiperazines/metabolism*; Amino Acids
From: Chinese Journal of Biotechnology 2023;39(11):4497-4516
CountryChina
Language:Chinese
Abstract: Cyclodipeptide (CDP) composed of two amino acids is the simplest cyclic peptide. These two amino acids form a typical diketopiperazine (DKP) ring by linking each other with peptide bonds. This characteristic stable ring skeleton is the foundation of CDP to display extensive and excellent bioactivities, which is beneficial for CDPs' pharmaceutical research and development. The natural CDP products are well isolated from actinomycetes. These bacteria can synthesize DKP backbones with nonribosomal peptide synthetase (NRPS) or cyclodipeptide synthase (CDPS). Moreover, actinomycetes could produce a variety of CDPs through different enzymatic modification. The presence of these abundant and diversified catalysis indicates that actinomycetes are promising microbial resource for exploring CDPs. This review summarized the pathways for DKP backbones biosynthesis and their post-modification mechanism in actinomycetes. The aim of this review was to accelerate the genome mining of CDPs and their isolation, purification and structure identification, and to facilitate revealing the biosynthesis mechanism of novel CDPs as well as their synthetic biology design.