Application of gelatin microspheres in bone tissue engineering.

Yuanhang Zhai; Jing LI; Abudukahaer Abuduaini; Zijiao Yang; Zhiruo YU; Yixuan Chen; Hao Liu; Xin Rong

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Application of gelatin microspheres in bone tissue engineering.

Author: Yuanhang ZHAI ¹ ; Jing LI ¹ ; Abudukahaer ABUDUAINI ¹ ; Zijiao YANG ¹ ; Zhiruo YU ¹ ; Yixuan CHEN ¹ ; Hao LIU ¹ ; Xin RONG ¹
Author Information

1. Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Publication Type:Journal Article
Keywords: bone repair; bone tissue engineering; cell culture; drug delivery; gelatin microspheres; preparation method; scaffold
MeSH: Tissue Engineering/methods*; Tissue Scaffolds/chemistry*; Gelatin/chemistry*; Microspheres; Bone and Bones; Porosity
From: Chinese Journal of Biotechnology 2023;39(9):3724-3737
CountryChina
Language:Chinese
Abstract: Gelatin microspheres were discussed as a scaffold material for bone tissue engineering, with the advantages of its porosity, biodegradability, biocompatibility, and biosafety highlighted. This review discusses how bone regeneration is aided by the three fundamental components of bone tissue engineering-seed cells, bioactive substances, and scaffold materials-and how gelatin microspheres can be employed for in vitro seed cell cultivation to ensure efficient expansion. This review also points out that gelatin microspheres are advantageous as drug delivery systems because of their multifunctional nature, which slows drug release and improves overall effectiveness. Although gelatin microspheres are useful for bone tissue creation, the scaffolds that take into account their porous structure and mechanical characteristics might be difficult to be created. This review then discusses typical techniques for creating gelatin microspheres, their recent application in bone tissue engineering, as well as possible future research directions.