Effect of uridine on mitochondrial function.

Author: Xueyi BAI ¹ ; Ding HUANG ² ; Pan XIE ² ; Ruiqiang SUN ² ; Hang ZHOU ² ; Yu LIU ¹
Author Information

1. School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 211100, Jiangsu, China.
2. Cell Culture Process Development Department, Shanghai WuXi Biologics Co., Ltd., Shanghai 200131, China.
Publication Type:Journal Article
Keywords: mitochondria; mitochondrial ATP-dependent potassium channels; pyrimidine nucleotide pool; uridine
MeSH: Uridine/metabolism*; Mitochondria/metabolism*
From: Chinese Journal of Biotechnology 2023;39(9):3695-3709
CountryChina
Language:Chinese
Abstract: Uridine is one of the essential nutrients in organisms. To maintain normal cell growth and intracellular metabolism, the uridine must be maintained at certain concentration. Recent studies have shown that uridine can reduce inflammatory response in organisms, participate in glycolysis, and regulate intracellular protein modification, such as glycosylation and acetylation. Furthermore, it can protect cells from hypoxic injury by reducing intracellular oxidative stress, promoting high-energy compounds synthesis. Previous studies have shown that the protective effects of uridine are closely related to its effect on mitochondria. This review summarizes the effect of uridine on mitochondrial function.