Application of quantitative proteomics in the study of acute mountain sickness.

Author: Bodan TU ¹ ; Xue WEI ² ; Huiying SHANG ² ; Zuoxu LIU ² ; Yihao WANG ² ; Yue GAO ¹
Author Information

1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi, China.
2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China.
Publication Type:Journal Article
Keywords: acute mountain sickness; biomarkers; hypobaric hypoxia; plateau acclimatization; quantitative proteomics
MeSH: Humans; Altitude Sickness/prevention & control*; Proteomics; Acute Disease; Oxygen/metabolism*
From: Chinese Journal of Biotechnology 2023;39(9):3594-3604
CountryChina
Language:Chinese
Abstract: Acute mountain sickness (AMS) is a clinical syndrome of multi-system physiological disorder after acute exposure to low pressure and low oxygen at high altitude. Quantitative proteomics can systematically quantify and describe protein composition and dynamic changes. In recent years, quantitative proteomics has been widely used in the prevention, diagnosis, treatment and pathogenesis of many diseases. This review summarizes the progress of quantitative proteomics techniques and its application in the prevention, diagnosis, treatment of AMS and mechanisms of rapidly acclimatizing to plateau, in order to provide a reference for the pathogenesis, early intervention, clinical treatment and proteomic research of AMS.