- Author:
Yanmei LI
1
;
Yunlin WEI
1
;
Haiyan LI
2
;
Xiuling JI
2
Author Information
- Publication Type:Journal Article
- Keywords: auxiliary metabolic genes (AMGs); fatty acid metabolism; glutamine metabolism; glycolysis; viral infections
- MeSH: Humans; Metabolic Networks and Pathways; Virus Diseases; Carbohydrate Metabolism; Host Microbial Interactions; Lipid Metabolism
- From: Chinese Journal of Biotechnology 2023;39(9):3566-3578
- CountryChina
- Language:Chinese
- Abstract: As specialized intracellular parasite, viruses have no ability to metabolize independently, so they completely depend on the metabolic mechanism of host cells. Viruses use the energy and precursors provided by the metabolic network of the host cells to drive their replication, assembly and release. Namely, viruses hijack the host cells metabolism to achieve their own replication and proliferation. In addition, viruses can also affect host cell metabolism by the expression of auxiliary metabolic genes (AMGs), affecting carbon, nitrogen, phosphorus, and sulfur cycles, and participate in microbial-driven biogeochemical cycling. This review summarizes the effect of viral infection on the host's core metabolic pathway from four aspects: cellular glucose metabolism, glutamine metabolism, fatty acid metabolism, and viral AMGs on host metabolism. It may facilitate in-depth understanding of virus-host interactions, and provide a theoretical basis for the treatment of viral diseases through metabolic intervention.