Advances in enzymatic production of L-homophenylalanine.

Author: Dengke GAO ¹ ; Wei SONG ² ; Wanqing WEI ¹ ; Kangping HUANG ² ; Jing WU ² ; Liming LIU ¹
Author Information

1. State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: L-homophenylalanine; Puli drugs; biocatalysis; multienzyme cascade
MeSH: Amino Acids; Environmental Pollution; Industry; Protein Biosynthesis
From: Chinese Journal of Biotechnology 2023;39(8):3111-3124
CountryChina
Language:Chinese
Abstract: L-homophenylalanine (L-HPA) is an important non-natural amino acid that has been used as a key intermediate for the synthesis of Puli drugs for the treatment of hypertension. At present, L-HPA is synthesized using chemical methods, which has the disadvantages of expensive raw materials, tedious steps and serious pollution. Therefore, researchers have conducted in-depth research on the enzymatic production of L-HPA. This review summarizes the research progress on the enzymatic synthesis of L-HPA, including the dehydrogenase process, the transaminase process, the hydantoinase process, and the decarboxylase process, with the hope to facilitate the industrial production of L-HPA.