Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor.
10.7518/hxkq.2023.2023035
- Author:
Zeliang SHEN
1
;
Lihong YAO
1
;
Hongjie JIANG
1
;
Mao LI
1
;
Yaling TANG
1
Author Information
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
clinicopathology;
granular cell tumor;
immunohistochemistry
- MeSH:
Humans;
Ki-67 Antigen/metabolism*;
Granular Cell Tumor/surgery*;
Retrospective Studies;
Actins/metabolism*;
Desmin/metabolism*;
S100 Proteins/metabolism*
- From:
West China Journal of Stomatology
2023;41(4):414-420
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To analyze the clinicopathological features of maxillofacial granular cell tumors (GCT) with the aid of immunohistochemical staining.
METHODS:Seven cases of maxillofacial GCT were retrospectively collated, and the microscopic morphology of maxillofacial GCT was analyzed. The expression of S-100, neuron-specific enolase (NSE), SOX-10, CD68, actin, desmin, and Ki-67 in GCT was detected by immunohistochemical staining. The cases were observed in the follow-ups after clinical treatment.
RESULTS:All seven GCT tumors lacked envelopes and were poorly defined. Microscopically, the sizes of the tumor cells were large and appeared with inconspicuous cell membranes, forming a syncytium-like appearance. The cytoplasm was filled with characteristic eosinophilic granules. The immunohistochemical results showed that six cases were NSE-positive, five cases were S-100-positive, seven cases were CD68-positive, five cases were SOX-10-positive, one case was actin-positive, and seven cases were desmin-negative. The Ki-67 index did not exceed 5% in all cases. In the follow-up sessions, none of the six cases presented a recurrence.
CONCLUSIONS:Maxillofacial GCT has a characteristic histological structure. Immunohistochemical S-100, CD68, and other indicators can assist in diagnosis, and the prognosis is good after clinical resection.
