Value of Pretreatment Inflammation-nutrition Score to Predict Non-response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer.

Guo Chao Zhang; Yan Yan XU; Ying Chao WU; Nuo Cheng; Rui Lian; Xin Wang

Return

Value of Pretreatment Inflammation-nutrition Score to Predict Non-response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer.

Author: Guo Chao ZHANG ^{1
,

2} ; Yan Yan XU ³ ; Ying Chao WU ⁴ ; Nuo CHENG ⁵ ; Rui LIAN ⁶ ; Xin WANG ⁴
Author Information

1. Department of General Surgery, Peking University First Hospital, Beijing 100034, China
2. Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
3. Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
4. Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
5. Beijing University of Chinese Medicine, Beijing 100029, China.
6. Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Publication Type:Journal Article
Keywords: Inflammation-nutrition score; Neoadjuvant chemotherapy; Rectal cancer; Tumor regression grade
MeSH: Humans; Retrospective Studies; Neoadjuvant Therapy; Lymphocytes; Biomarkers; Rectal Neoplasms/pathology*
From: Biomedical and Environmental Sciences 2023;36(10):940-948
CountryChina
Language:English
Abstract: OBJECTIVE:To investigate the value of pretreatment inflammatory-nutritional biomarkers in predicting the pathological response of locally advanced rectal cancer (LARC) after neoadjuvant chemotherapy (nCT).
METHODS:This retrospective study included eligible participants who underwent nCT followed by radical surgery. Pretreatment inflammatory nutritional biomarkers were calculated within one week prior to nCT. Correlations between biomarkers and pathological responses were analyzed. The cut-off values of the pretreatment biomarkers for predicting non-response were determined using receiver operating characteristic (ROC) curve analysis. The inflammation-nutrition score was calculated using the lymphocyte level, neutrophil-to-lymphocyte ratio (NLR), and prognostic nutritional index (PNI).
RESULTS:A total of 235 patients were retrospectively recruited between January 2017 and September 2022. Lower lymphocyte levels, lymphocyte monocyte ratio (LMR), and PNI, and higher NLR and platelet-to-lymphocyte ratio (PLR) were observed in patients without response. Multivariate logistic regression analysis revealed that NLR could independently predict non-response to nCT in patients with LARC. The sensitivity and specificity of the inflammation-nutrition score for predicting nonresponse were 71.2% and 61.7%, respectively.
CONCLUSION:The pretreatment inflammation-nutrition score is a practical parameter for predicting non-response to nCT in patients with LARC. Patients with high scores were more likely to respond poorly to nCT.