Treatment Outcomes in COVID-19 Patients with Brucellosis: Case Series in Heilongjiang and Systematic Review of Literature.

Man Li Yang; Jing Ya Wang; Xing Yu Zong; Li Guan; Hui Zhen LI; Yi Bai Xiong; Yu Qin Liu; Ting LI; Xin Yu JI; Xi Yu Shang; Hui Fang Zhang; Yang Guo; Zhao Yuan Gong; Lei Zhang; Lin Tong; Ren Bo Chen; Yi Pin Fan; Jin Qin; Fang Wang; Gang Lin; Nan Nan Shi; Yan Ping Wang; Yan MA

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Treatment Outcomes in COVID-19 Patients with Brucellosis: Case Series in Heilongjiang and Systematic Review of Literature.

Author: Man Li YANG ¹ ; Jing Ya WANG ^{2
,

3} ; Xing Yu ZONG ³ ; Li GUAN ⁴ ; Hui Zhen LI ³ ; Yi Bai XIONG ³ ; Yu Qin LIU ⁴ ; Ting LI ⁴ ; Xin Yu JI ³ ; Xi Yu SHANG ³ ; Hui Fang ZHANG ³ ; Yang GUO ³ ; Zhao Yuan GONG ³ ; Lei ZHANG ⁵ ; Lin TONG ⁵ ; Ren Bo CHEN ³ ; Yi Pin FAN ³ ; Jin QIN ⁶ ; Fang WANG ⁷ ; Gang LIN ⁴ ; Nan Nan SHI ³ ; Yan Ping WANG ³ ; Yan MA ³
Author Information

1. Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
2. Community Health Service Management Center, Dongcheng District, Beijing 100700, China
3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
4. Infectious Disease Hospital of Heilongjiang Province, Harbin 150030, Heilongjiang, China.
5. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
6. Beijing University of Chinese Medicine, Beijing 101121, China.
7. Community Health Service Management Center, Dongcheng District, Beijing 100700, China.
Publication Type:Systematic Review
Keywords: Brucellosis; COVID-19; Relapse; Sequelae; Treatment outcomes
MeSH: Female; Humans; Male; Middle Aged; Brucellosis; COVID-19; Retrospective Studies; SARS-CoV-2; Treatment Outcome; Case Reports as Topic
From: Biomedical and Environmental Sciences 2023;36(10):930-939
CountryChina
Language:English
Abstract: OBJECTIVE:Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated, we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after recovery.
METHODS:We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15, 2020 to April 29, 2022. Demographics, epidemiological, clinical symptoms, radiological and laboratory data, treatment medicines and outcomes, and follow up were analyzed, and findings of a systematic review were demonstrated.
RESULTS:A total of four COVID-19 with brucellosis patients were included. One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis. The median age was 54.5 years, and all were males (100.0%). Two cases (50.0%) were moderate, and one was mild and asymptomatic, respectively. Three cases (75.0%) had at least one comorbidity (brucellosis excluded). All 4 patients were found in COVID-19 nucleic acid screening. Case C and D had only headache and fever on admission, respectively. Four cases were treated with Traditional Chinese medicine, western medicines for three cases, no adverse reaction occurred during hospitalization. All patients were cured and discharged. Moreover, one case (25.0%) had still active brucellosis without re-positive COVID-19, and other three cases (75.0%) have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery. Conducting the literature review, two similar cases have been reported in two case reports, and were both recovered, whereas, no data of follow up after recovery.
CONCLUSION:These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after recovery. More clinical studies should be conducted to confirm our findings.