Isolation of <i>Leclercia adecarboxylata</i> Producing Carbapenemases in A Newborn Female.

Shuang Meng; Bei Bei Miao; Jie LI; Jian Wen Yin; Ze Liang Liu; Xue Qi Jiang; Xin Yi Gong; Juan LI

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Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female.

Author: Shuang MENG ^{1
,

2} ; Bei Bei MIAO ² ; Jie LI ² ; Jian Wen YIN ³ ; Ze Liang LIU ² ; Xue Qi JIANG ² ; Xin Yi GONG ² ; Juan LI ²
Author Information

1. Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2. State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
3. Yunnan Center for Disease Control and Prevention, Kunming 650034, Yunnan, China.
Publication Type:Letter
Keywords: Carbapenem-resistant; Leclercia adecarboxylata; Newborn
MeSH: Infant, Newborn; Child; Humans; Female; Enterobacteriaceae Infections/microbiology*; Enterobacteriaceae/genetics*; Anti-Bacterial Agents/therapeutic use*; Plasmids
From: Biomedical and Environmental Sciences 2023;36(9):874-879
CountryChina
Language:English
Abstract: Leclercia adecarboxylata is a Gram-negative bacterium belonging to the Enterobacteriaceae family. To our knowledge, this is the first report of a carbapenem-resistant L. adecarboxylata strain isolated from a healthy newborn. The L. adecarboxylata strain isolated in this study carried four plasmids that may serve as reservoirs for antibiotic resistance genes. Plasmids 2 and 4 did not harbor any antimicrobial resistance genes. Plasmid 3 is a novel plasmid containing three resistance genes. The bla _IMP gene harbored in the strain was most similar to bla _IMP-79 at the nucleotide level, with a similarity of 99.4% (737/741). This case highlights the importance of considering L. adecarboxylata as a potential cause of infections in children.