Role of Prognostic Marker <i>PRR11</i> in Immune Infiltration for Facilitating Lung Adenocarcinoma Progression.

Wen Hao Wang; Chang Geng MA; Yun Shang Cui; Bing Yu Bai; Zhi Mei Sheng; Jin Liu; Ao LI; Bao Gang Zhang

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Role of Prognostic Marker PRR11 in Immune Infiltration for Facilitating Lung Adenocarcinoma Progression.

Author: Wen Hao WANG ^{1
,

2} ; Chang Geng MA ² ; Yun Shang CUI ³ ; Bing Yu BAI ⁴ ; Zhi Mei SHENG ² ; Jin LIU ² ; Ao LI ² ; Bao Gang ZHANG ^{1
,

2}
Author Information

1. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
2. Affiliated Hospital of Weifang Medical University, Weifang 261041, Shandong, China.
3. Chinese Center for Disease Control and Prevention, Beijing 102206, China.
4. Weifang Medical University, Weifang 261053, Shandong, China.
Publication Type:Letter
Keywords: Bioinformatics; Cell cycle; Lung adenocarcinoma; PRR11; Th2 cell
MeSH: Humans; Prognosis; Adenocarcinoma of Lung/genetics*; Lung Neoplasms/genetics*; Biological Assay; Cell Cycle
From: Biomedical and Environmental Sciences 2023;36(9):862-868
CountryChina
Language:English
Abstract: The PRR11 gene (Proline Rich 11) has been implicated in lung cancer; however, relationship between PRR11 and immune infiltration is not clearly understood. In this study, we used The Cancer Genome Atlas (TCGA) data to analyze the lung adenocarcinoma patients; PRR11 gene expression, clinicopathological findings, enrichment, and immune infiltration were also studied. PRR11 immune response expression assays in lung adenocarcinoma (LUAD) were performed using TIMER, and statistical analysis and visualization were conducted using R software. All data were verified using Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA). We found that PRR11 was an important prognostic factor in patients with LUAD. PRR11 expression was correlated with tumor stage and progression. Gene Set Enrichment Analysis (GSEA) showed that PRR11 was enriched in the cell cycle regulatory pathways. Immune infiltration analysis revealed that the number of T helper 2 (Th2) cells increased when PRR11 was overexpressed. These results confirm the role of PRR11 as a prognostic marker of lung adenocarcinoma by controlling the cell cycle and influencing the immune system to facilitate lung cancer progression.