Advances in live-imaging aging reporter mice.
- Author:
Jie SUN
1
;
Yu-Ning WANG
2
;
Shan-Shan LUO
3
;
Bao-Hua LIU
1
Author Information
1. School of Basic Medical Science, Shenzhen University, Shenzhen 518060, China.
2. Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
3. Luohu Clinical Institute of Shantou University Medical College, Shenzhen 518005, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Animals;
Mice;
Aged;
Aging;
Cyclin-Dependent Kinase Inhibitor p16/metabolism*;
Cyclin-Dependent Kinase Inhibitor p21/metabolism*;
Biomarkers;
Tumor Suppressor Protein p53
- From:
Acta Physiologica Sinica
2023;75(6):836-846
- CountryChina
- Language:Chinese
-
Abstract:
Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16Ink4a, p21Waf1/Cip1, p53 and Glb1), and discusses their applications in aging research.
