Research advances in the role of Rab GTPases in Alzheimer's disease.
- Author:
Jing ZHANG
1
;
Hai-Tian JIANG
1
;
Dao-Bin HAN
1
;
Hui YU
1
;
Lu-Wen WANG
2
;
Bo SU
3
Author Information
1. School of Basic Medical Science, Shandong University, Jinan 250012, China.
2. Advanced Medical Research Institute, Shandong University, Jinan 250012, China.
3. School of Basic Medical Science, Shandong University, Jinan 250012, China. bxs103@sdu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Alzheimer Disease;
rab GTP-Binding Proteins/metabolism*;
Amyloid beta-Peptides/metabolism*;
tau Proteins/metabolism*
- From:
Acta Physiologica Sinica
2023;75(6):817-835
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular deposition of β-amyloid (Aβ) and intracellular hyperphosphorylated tau are the predominant pathological changes in Alzheimer's disease (AD). Increasing evidence demonstrates a critical role of a variety of small GTPases, namely Ras-related proteins (Rabs), in the pathogenesis of AD. As crucial regulators of intracellular membrane trafficking, alteration in Rab protein expression and function represents one of the primary factors contributing to the abnormal membrane trafficking in AD. Additionally, the Rab GTPases are also involved in the development of Aβ, tau and other pathological changes associated with AD. In this article, we conduct a comprehensive review on the primary functions of multiple Rab proteins and their involvement in the pathogenesis of AD.
