Environmental pollutants and Alzheimer's disease.
- Author:
Bao GUO
1
;
Qian BA
1
Author Information
1. Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Alzheimer Disease/chemically induced*;
Environmental Pollutants/toxicity*;
Neurodegenerative Diseases;
Plastics;
Amyloid beta-Peptides/metabolism*
- From:
Acta Physiologica Sinica
2023;75(6):740-766
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment. The main hypotheses about the pathogenesis of AD include the hypothesis of β-amyloid protein, the hypothesis of abnormal phosphorylation of Tau protein, and the hypothesis of neuroinflammation. In recent years, environmental pollutants have been considered as an important factor in causing neurological dysfunction. Common environmental pollutants include heavy metals, pesticides, polychlorinated biphenyls, microplastics, and air pollutants, all of which have been proven to have neurotoxicity. In this review, we not only discussed epidemiological and animal experimental studies that link environmental pollution with AD, but also summarized the mechanisms of action of relevant toxins, providing insights for studying the interrelationships between environmental pollutants and AD.
