Research progress on the biological effects of HIF-1α on follicle development and ovulation.
- Author:
Lin-Na MA
1
;
Kun MA
2
;
Xiao-Di FAN
3
;
Han ZHANG
1
;
Jia-Ni LI
4
;
Shan-Feng GAO
4
Author Information
1. Graduate School, Tianjin University of Chinese Medicine, Tianjin 301617, China.
2. Department of Continuing Education, China Academy of Chinese Medical Sciences, Beijing 100700, China. mkun1230@163.com.
3. Beijing Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. xiaodi.1018@163.com.
4. Gynecology Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Atrophy/metabolism*;
Hypoxia;
Hypoxia-Inducible Factor 1, alpha Subunit/metabolism*;
Infertility/metabolism*;
Ovarian Follicle;
Ovulation
- From:
Acta Physiologica Sinica
2023;75(5):727-735
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor-1α (HIF-1α), as a hypoxia inducible factor, affects women's reproductive function by regulating the development and excretion of follicles. HIF-1α induces glycolysis and autophagy in the granule cells by promoting oocyte development, regulating the secretion of related angiogenic factors, and improving follicle maturity. In addition, HIF-1α promotes the process of luteinization of follicular vesicles, maintains luteal function, and finally completes physiological luteal atrophy through cumulative oxidative stress. Dysfunction of HIF-1α will cause a series of pathological consequences, such as angiogenesis defect, energy metabolism abnormality, excessive oxidative stress and dysregulated autophagy and apoptosis, resulting in ovulation problem and infertility. This article summarizes the previous studies on the regulation of follicle development and excretion and maintenance of luteal function and structural atrophy by HIF-1α. We also describe the effective intervention mechanism of related drugs or bioactive ingredients on follicular dysplasia and ovulation disorders through HIF-1α, in order to provide a systematic and in-depth insights for solving ovulation disorder infertility.
