Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases.
- Author:
Meng-Yuan YU
1
;
Zhen-Jun TIAN
2
Author Information
1. Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi'an 710119, China.
2. Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi'an 710119, China. tianzhj@snnu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Neurodegenerative Diseases/therapy*;
Guanine Nucleotide Exchange Factors/metabolism*;
Exercise Therapy
- From:
Acta Physiologica Sinica
2023;75(5):659-670
- CountryChina
- Language:Chinese
-
Abstract:
Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, accompanied by abnormal expression of Kal-7, which in turn induces a variety of neurodegenerative diseases. Exercise can upregulate the expression of Kal-7 in related brain regions to alleviate neurodegenerative diseases. By reviewing the literature on Kal-7 and neurodegenerative diseases, as well as the research progress of exercise intervention, this paper summarizes the role and possible mechanism of Kal-7 in the improvement of neurodegenerative diseases by exercise and provides a new rationale for the basic and clinical research on the prevention and treatment of neurodegenerative diseases by exercise.
