Research advances on the role of ACSL3 in the atherosclerosis.
- Author:
Li YANG
1
;
Zhong-Hua YUAN
2
Author Information
1. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang 421001, China.
2. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang 421001, China. yzh5555@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Atherosclerosis;
Coenzyme A Ligases/metabolism*;
Endoplasmic Reticulum/metabolism*;
Fatty Acids/metabolism*;
Lipid Metabolism
- From:
Acta Physiologica Sinica
2023;75(4):587-594
- CountryChina
- Language:Chinese
-
Abstract:
Lipids droplets are organelles that store neutral lipids and are closely related to lipid accumulation. Long chain acyl-coenzyme A synthetase 3 (ACSL3) is a lipid droplet-associated protein mainly distributed in the cell membrane, endoplasmic reticulum, and intracellular lipid droplets, and its distribution depends on cell type and fatty acid supply. ACSL3 is a key regulator of fatty acid metabolism that is closely related to intracellular lipid accumulation, and plays an important role in various pathophysiological processes such as lipid droplet synthesis and lipid metabolism, cellular inflammation, and ferroptosis. This paper mainly reviews the role of ACSL3 in lipid synthesis, ferroptosis, and inflammatory response, with focus on the mechanism of its role in lipid accumulation in atherosclerosis, and provides new ideas for exploring potential therapeutic targets in atherosclerotic diseases.
