Research progress in the mechanism and treatment of osteosarcoma.
10.1097/CM9.0000000000002800
- VernacularTitle:Research progress in the mechanism and treatment of osteosarcoma
- Author:
Jichao BIAN
1
;
Yang LIU
2
;
Xiaowei ZHAO
1
;
Chunyang MENG
3
;
Yuanmin ZHANG
1
;
Yangmiao DUAN
4
;
Guodong WANG
1
Author Information
1. Department of Joint and Sports Medicine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China.
2. Department of Pathology, The Second People's Hospital Of Jining, Jining, Shandong 272049, China.
3. Department of Spine, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China.
4. Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
- Publication Type:Journal Article
- MeSH:
Child;
Adolescent;
Humans;
Bone Neoplasms/drug therapy*;
Signal Transduction;
Bone and Bones/metabolism*;
Treatment Outcome;
Osteosarcoma/drug therapy*;
Tumor Microenvironment
- From:
Chinese Medical Journal
2023;136(20):2412-2420
- CountryChina
- Language:English
-
Abstract:
Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research.
