Effect of arteriosclerotic intracranial arterial vessel wall enhancement on downstream collateral flow.
10.1097/CM9.0000000000002307
- Author:
Liqun YAN
1
;
Jin YAN
2
;
Zhenchang WANG
1
;
Guoshi WANG
3
;
Zhenzhong LI
4
;
Yaping HOU
5
;
Boyuan HUANG
3
;
Qianbo DONG
3
;
Xiaodan MU
3
;
Wei CAO
3
;
Pengfei ZHAO
1
Author Information
1. Department of Radiology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China.
2. Department of Clinical Medicine, Tianjin Medical University, Tianjin 300203, China.
3. Departments of Medical Imaging, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China.
4. Departments of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, China.
5. Hebei Province Blood Center, Shijiazhuang, Hebei 050000, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Constriction, Pathologic/pathology*;
Magnetic Resonance Imaging/methods*;
Middle Cerebral Artery/pathology*;
Tomography, X-Ray Computed
- From:
Chinese Medical Journal
2023;136(18):2221-2228
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The effect of arteriosclerotic intracranial arterial vessel wall enhancement (IAVWE) on downstream collateral flow found in vessel wall imaging (VWI) is not clear. Regardless of the mechanism underlying IAVWE on VWI, damage to the patient's nervous system caused by IAVWE is likely achieved by affecting downstream cerebral blood flow. The present study aimed to investigate the effect of arteriosclerotic IAVWE on downstream collateral flow.
METHODS:The present study recruited 63 consecutive patients at the Second Hospital of Hebei Medical University from January 2021 to November 2021 with underlying atherosclerotic diseases and unilateral middle cerebral artery (MCA) M1-segment stenosis who underwent an magnetic resonance scan within 3 days of symptom onset. The patients were divided into 4 groups according to IAVWE and the stenosis ratio (Group 1, n = 17; Group 2, n = 19; Group 3, n = 13; Group 4, n = 14), and downstream collateral flow was analyzed using three-dimensional pseudocontinuous arterial spin labeling (3D-pCASL) and RAPID software. The National Institutes of Health Stroke Scale (NIHSS) scores of the patients were also recorded. Two-factor multivariate analysis of variance using Pillai's trace was used as the main statistical method.
RESULTS:No statistically significant difference was found in baseline demographic characteristics among the groups. IAVWE, but not the stenosis ratio, had a statistically significant significance on the late-arriving retrograde flow proportion (LARFP), hypoperfusion intensity ratio (HIR), and NIHSS scores ( F = 20.941, P <0.001, Pillai's trace statistic = 0.567). The between-subject effects test showed that IAVWE had a significant effect on the three dependent variables: LARFP ( R2 = 0.088, F = 10.899, P = 0.002), HIR ( R2 = 0.234, F = 29.354, P <0.001), and NIHSS ( R2 = 114.339, F = 33.338, P <0.001).
CONCLUSIONS:Arteriosclerotic IAVWE significantly reduced downstream collateral flow and affected relevant neurological deficits. It was an independent factor affecting downstream collateral flow and NIHSS scores, which should be a focus of future studies.
TRIAL REGISTRATION:ChiCTR.org.cn, ChiCTR2100053661.
