Effects of radiation therapy on tumor microenvironment: an updated review.
10.1097/CM9.0000000000002535
- VernacularTitle:Effects of radiation therapy on tumor microenvironment: an updated review
- Author:
Zewen ZHANG
1
;
Yuanhao PENG
2
;
Xin PENG
2
;
Desheng XIAO
2
;
Ying SHI
1
;
Yongguang TAO
1
Author Information
1. NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China.
2. Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Neoplasms/pathology*;
Lung Neoplasms/complications*;
Fibroblasts/pathology*;
Biomarkers;
Macrophages/pathology*;
Hypoxia;
Tumor Microenvironment
- From:
Chinese Medical Journal
2023;136(23):2802-2811
- CountryChina
- Language:English
-
Abstract:
Cancer is a major threat to human health and causes death worldwide. Research on the role of radiotherapy (RT) in the treatment of cancer is progressing; however, RT not only causes fatal DNA damage to tumor cells, but also affects the interactions between tumor cells and different components of the tumor microenvironment (TME), including immune cells, fibroblasts, macrophages, extracellular matrix, and some soluble products. Some cancer cells can survive radiation and have shown strong resistance to radiation through interaction with the TME. Currently, the complex relationships between the tumor cells and cellular components that play major roles in various TMEs are poorly understood. This review explores the relationship between RT and cell-cell communication in the TME from the perspective of immunity and hypoxia and aims to identify new RT biomarkers and treatment methods in lung cancer to improve the current status of unstable RT effect and provide a theoretical basis for further lung cancer RT sensitization research in the future.
