Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway.
10.1097/CM9.0000000000002541
- Author:
Yujie XU
1
;
Shufang SHAN
1
;
Xiaoyu WANG
1
;
Lingli LI
2
;
Liang MA
3
;
Jingyuan XIONG
4
;
Ping FU
3
;
Guo CHENG
1
Author Information
1. Department of Pediatrics, Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
2. West China School of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
3. Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
4. Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
- Publication Type:Journal Article
- MeSH:
Proto-Oncogene Proteins c-akt/metabolism*;
Butyrates;
Ligands;
Glucose;
Receptors, G-Protein-Coupled/metabolism*;
Glycogen Synthase Kinases/metabolism*;
Glycogen Synthase Kinase 3 beta;
Phosphorylation
- From:
Chinese Medical Journal
2023;136(19):2368-2370
- CountryChina
- Language:English
