Application of decellularization-recellularization technique in plastic and reconstructive surgery.
10.1097/CM9.0000000000002085
- Author:
Yujia SHANG
1
;
Guanhuier WANG
1
;
Yonghuan ZHEN
1
;
Na LIU
1
;
Fangfei NIE
1
;
Zhenmin ZHAO
1
;
Hua LI
2
;
Yang AN
1
Author Information
1. Department of Plastic Surgery, Peking University Third Hospital, Haidian District, Beijing 100191, China.
2. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
- Publication Type:Journal Article
- MeSH:
Tissue Engineering/methods*;
Tissue Scaffolds/chemistry*;
Surgery, Plastic;
Regenerative Medicine/methods*;
Extracellular Matrix
- From:
Chinese Medical Journal
2023;136(17):2017-2027
- CountryChina
- Language:English
-
Abstract:
In the field of plastic and reconstructive surgery, the loss of organs or tissues caused by diseases or injuries has resulted in challenges, such as donor shortage and immunosuppression. In recent years, with the development of regenerative medicine, the decellularization-recellularization strategy seems to be a promising and attractive method to resolve these difficulties. The decellularized extracellular matrix contains no cells and genetic materials, while retaining the complex ultrastructure, and it can be used as a scaffold for cell seeding and subsequent transplantation, thereby promoting the regeneration of diseased or damaged tissues and organs. This review provided an overview of decellularization-recellularization technique, and mainly concentrated on the application of decellularization-recellularization technique in the field of plastic and reconstructive surgery, including the remodeling of skin, nose, ears, face, and limbs. Finally, we proposed the challenges in and the direction of future development of decellularization-recellularization technique in plastic surgery.
