Outcome of Early Diagnos is and Hemodialys is in Acute Renal Failure due to Metformin-associated Lactic Acidosis in Elderly Type 2 Diabetes Mellitus Patient.
- Author:
Jong Dae BONG
1
;
Sang Hyuk KWAK
;
Kyu Bom BOO
;
Doo Son SIM
;
Tae Woong LEE
Author Information
1. Depatment of Int ernal Medicine, Koheug General Hospi tal , Chonnam, Korea. bong2888@lycos.co.kr
- Publication Type:Case Report
- Keywords:
Metformin;
Lactic acidosis;
Acute renal failure
- MeSH:
Acidosis, Lactic*;
Acute Kidney Injury*;
Aged*;
Blood Proteins;
Diabetes Mellitus;
Diabetes Mellitus, Type 2*;
Early Diagnosis;
Humans;
Kidney;
Metformin;
Prognosis;
Renal Dialysis;
Renal Insufficiency
- From:Journal of the Korean Geriatrics Society
2004;8(2):115-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metformin is a biguanide oral hypoglycemic agent commonly used in the treatment of diabetes mellitus. Metfofmin is excreated largely by the kidney and binds only negligibly to plasma proteins. Toxicity is usually seen when metformin is prescribed to patients with renal insufficiency. Lactic acidosis in diabetics on metformin therapy is rare but still associated with poor prognosis. For an early diagnosis, clinical symptoms of intoxication should be well known by physicians and patients. First-line therapy for correction of lactic acidosis and effective elimination of metformin is bicarbonate hemodialysis. We report a case of acute renal failure due to metformin-associated lactic acidosis in elderly type 2 diabetes mellitus patient and she was successfully treated by hemodialysis with bicarbonate buffer.
