More microinvasive foci in larger tumours of breast ductal carcinoma <i>in situ</i>.

Xiao-yang Chen; Aye Aye Thike; Johnathan Xiande Lim; Boon Huat Bay; Puay Hoon Tan

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More microinvasive foci in larger tumours of breast ductal carcinoma in situ.

Author: Xiao-Yang CHEN ^{1
,

2} ; Aye Aye THIKE ^{3
,

4} ; Johnathan Xiande LIM ⁵ ; Boon Huat BAY ⁶ ; Puay Hoon TAN ^{1
,

4
,

7
,

8}
Author Information

1. Division of Pathology, Singapore General Hospital
2. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3. Duke-NUS Medical School
4. Department of Anatomical Pathology, Singapore General Hospital, Singapore.
5. Division of Pathology, Singapore General Hospital, Singapore.
6. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
7. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore
8. Duke-NUS Medical School
Publication Type:Journal Article
Keywords: DCIS; ipsilateral invasive recurrence; microinvasion; microinvasive foci; progression
MeSH: Humans; Female; Carcinoma, Intraductal, Noninfiltrating; Prognosis; Disease-Free Survival; Progression-Free Survival; Breast Neoplasms; Carcinoma, Ductal, Breast/pathology*; Neoplasm Invasiveness
From:Singapore medical journal 2023;64(8):493-496
CountrySingapore
Language:English
Abstract: INTRODUCTION:Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers.
METHODS:The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin-stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci.
RESULTS:Higher numbers of Mi foci were found in larger tumours (P = 0.031).
CONCLUSION:Greater extent of DCIS is associated with multifocal Mi.