Cognitive profile in mild cognitive impairment with Lewy bodies.

Shuai Liu; Chunyan Liu; Xiao-dan Wang; Huiru LU; Yong JI

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Cognitive profile in mild cognitive impairment with Lewy bodies.

Author: Shuai LIU ¹ ; Chunyan LIU ² ; Xiao-Dan WANG ¹ ; Huiru LU ³ ; Yong JI ^{4
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Author Information

1. Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
2. Department of Neurology, Aviation General Hospital, Beijing, China.
3. Department of Geratology, Tianjin First Central Hospital, Tianjin, China.
4. Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin
5. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Publication Type:Journal Article
Keywords: Clock-drawing test; Lewy bodies; Montreal cognitive assessment; mild cognitive impairment; mini-mental state examination
MeSH: Humans; Cognitive Dysfunction; Alzheimer Disease/diagnosis*; Neuropsychological Tests; Cognition
From:Singapore medical journal 2023;64(8):487-492
CountrySingapore
Language:English
Abstract: INTRODUCTION:This study aimed to elucidate the cognitive profile of patients with mild cognitive impairment with Lewy bodies (MCI-LB) and to compare it to that of patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD).
METHODS:Subjects older than 60 years with probable MCI-LB (n = 60) or MCI-AD (n = 60) were recruited. All patients were tested with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to assess their global cognitive profile.
RESULTS:The MCI-AD and MCI-LB patients did not differ in total MMSE and MoCA scores. However, some sub-items in MMSE and MoCA were shown to be screening markers for differentiating MCI-LB from MCI-AD. In the visuoconstructive test, the total score and hands subitem score in the clock-drawing test were significantly lower in MCI-LB than in MCI-AD. As for the executive function, the 'animal fluency test', 'repeat digits backward test' and 'take paper by your right hand' in MMSE all showed lower scores in MCI-LB compared with MCI-AD. As for memory, 'velvet' and 'church' in MoCA and 'ball' and 'national flag' in MMSE had lower scores in MCI-AD than in MCI-LB.
CONCLUSION:This study presents the cognitive profile of patients with MCI-LB. In line with the literature on Dementia with Lewy bodies, our results showed lower performance on tests for visuoconstructive and executive function, whereas memory remained relatively spared in the early period.