Association between deacetylase Sirtuins and radiation-induced liver disease
- VernacularTitle:去乙酰化酶Sirtuins家族与放射性肝病的关系
- Author:
Yekai ZONG
1
;
Jiangkai LIU
2
Author Information
- Publication Type:Review
- Keywords: Radiation-Induced Liver Disease; Sirtuins; Radiation， Ionizing
- From: Journal of Clinical Hepatology 2024;40(2):419-425
- CountryChina
- Language:Chinese
- Abstract: Radiation-induced liver disease （RILD）， also known as radiation hepatitis， is subacute liver injury induced by radiation. As the focus of senescence-related studies， the deacetylase family Sirtuins （SIRTs） have the molecular functions including DNA repair and chromatin regulation， which makes SIRTs a hub for regulating genome and epigenome stability. Radiation-induced hepatic DNA damage and reaction is the primary physiological and pathological process of RILD， which is similar to the function of SIRTs. This article briefly introduces the structure and function of the SIRTs protein family， elaborates on the basic concepts and progress of the physical physiology of radiation therapy， discusses the internal relationship between SIRTs and RILD from the perspective of radiobiology， and points out the possibility of SIRTs as a target for the prevention and treatment of RILD.
