Pathogenesis of liver injury caused by antiviral drugs for coronavirus disease 2019
- VernacularTitle:新型冠状病毒感染抗病毒药物引起肝损伤的发生机制
- Author:
Xue ZENG
1
;
Fuqing LI
1
;
Qingqing LI
1
;
Hong WANG
1
Author Information
- Publication Type:Review
- Keywords: Chemical and Drug Induced Liver Injury; SARS-CoV-2; Pathologic Processes
- From: Journal of Clinical Hepatology 2024;40(2):402-407
- CountryChina
- Language:Chinese
- Abstract: Drug-induced liver injury is caused by the drug itself and/or its metabolites during drug use or occurs due to hypersensitivity or reduced tolerance to the drug in a particular body type. In the last three years of the diagnosis and treatment of coronavirus disease 2019 （COVID-19）， antiviral drugs have played a very important role， but there are many reports on liver injury caused by anti-COVID-19 drugs in China and globally， with unknown pathogenesis of liver injury caused by such drugs. This article reviews the research advances in the types of antiviral drugs for COVID-19 and their mechanism in inducing liver injury， in order to promote the rational use of antiviral drugs.
