Role of NOD-like receptor protein 3 inflammasome in the development and progression of hepatocellular carcinoma

Xuehai YU; Bendong Chen; Yimin Liu; Yongxin MA; Xusheng Zhang; Hongcai Zhou; Haiyan MA

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Role of NOD-like receptor protein 3 inflammasome in the development and progression of hepatocellular carcinoma

VernacularTitle:NOD样受体蛋白3（NLRP3）炎性小体在肝细胞癌发生发展中的作用
Author: Xuehai YU ¹ ; Bendong CHEN ² ; Yimin LIU ³ ; Yongxin MA ³ ; Xusheng ZHANG ³ ; Hongcai ZHOU ³ ; Haiyan MA ³
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1. Department of Pediatric Surgery， General Hospital of Ningxia Medical University， Yinchuan 750000， China
2. Department of Hepatobiliary Surgery， General Hospital of Ningxia Medical University， Yinchuan 750000， China
3. Ningxia Medical University， Yinchuan 750000， China
Publication Type:Review
Keywords: Carcinoma， Hepatocellular; NLR Family， Pyrin Domain-Containing 3 Protein; Pyroptosis
From: Journal of Clinical Hepatology 2024;40(2):397-401
CountryChina
Language:Chinese
Abstract: In recent years， NOD-like receptor protein 3 （NLRP3） inflammasome in tumors has become a research hotspot， especially in melanoma， colorectal cancer， lung cancer， and breast cancer， and more and more evidence has shown that inflammation plays a role in the development， progression， angiogenesis， and invasion of cancer. Hepatocellular carcinoma （HCC） is the most common type of primary liver cancer， and there are still controversies over the role of NLRP3 inflammasome in the development and progression of HCC. Therefore， this article reviews the potential impact of NLRP3 inflammasome in the progression of HCC and its mechanism of action in anticancer therapy， and it is believed that NLRP3 inflammasome can be used as an effective therapeutic target for HCC patients.