Association of intestinal microecology with the development and progression of autoimmune hepatitis
- VernacularTitle:肠道微生态与自身免疫性肝炎发生发展的关系
- Author:
Yuyan XIA
1
;
Qiongrong ZENG
2
;
Fujian LI
2
;
Fengyan LI
3
;
Qi LI
3
;
Lixia TANG
1
;
Guo ZHANG
2
Author Information
- Publication Type:Review
- Keywords: Hepatitis， Autoimmune; Gastrointestinal Microbiome; Diagnosis; Therapeutics
- From: Journal of Clinical Hepatology 2024;40(2):374-379
- CountryChina
- Language:Chinese
- Abstract: Autoimmune hepatitis （AIH） is an autoimmune disease characterized by chronic liver inflammation， with a gradually increasing incidence rate， and its social and medical burdens cannot be neglected. Intestinal microecology is becoming a research hotspot in the field of autoimmune disease. In recent years， it has been believed that changes in intestinal microecology can cause changes in autoimmune state， microbial metabolites， and intestinal barrier， which is one of the driving factors for the onset of AIH. Early diagnosis and correct treatment can help to improve the prognosis of AIH patients. This article introduces the characteristics of gut microbiota in AIH patients， elaborates on the impact of intestinal microflora imbalance on the pathogenesis of AIH， and briefly describes related treatment regimens from the perspective of intestinal microecology， so as to comprehensively understand and explain the role of intestinal microecology in AIH and the impact of intestinal microecology balance on the pathogenesis， diagnosis， and treatment of AIH.
