The Effect of Equine Placental Extract on Anti-inflammatory and Anti-oxidant Activity of the Skin

VernacularTitle:ウマ胎盤抽出物による皮膚の抗炎症および抗酸化作用
Author: Shogo MORIWAKI ¹ ; Masafumi TAKABUCHI ¹ ; Yoshinobu TSURUTA ¹ ; Toshiyuki OZAWA ² ; Eiichi HIRANO ³ ; Hideya ANDO ¹
Author Information

1. Department of Applied Chemistry and Biotechnology, Okayama University of Science
2. Pharmaco-physiology & kinetics Collaborative Research Division, Osaka Metropolitan University, Graduate School of Medicine
3. Japan Bio Products, Co., Ltd. Research Institute
Keywords: Placental extract; Anti-inflammation; Ultraviolet; Nrf2; Keratinocyte
From:Japanese Journal of Complementary and Alternative Medicine 2023;20(1):19-23
CountryJapan
Language:Japanese
Abstract: The anti-inflammatory and anti-oxidant effect of equine placental extract (ePE) on epidermal keratinocytes was examined. ePE reduced mRNA levels of TNF-α (Tumor Necrosis Factor-α) and IL-6 (Interleukin-6) among the inflammatory cytokines released by epidermal keratinocytes after ultraviolet light (UVB: 290-320 nm) exposure. ePE also activated Nrf2, a transcription factor known to be activated by oxidative stress to promote the expression of antioxidant enzymes and suppress inflammation, and it increased the mRNA level of the antioxidant enzyme HO-1 (Heme Oxygenase-1). These results suggest that ePE suppresses UV-induced inflammation of epidermal keratinocytes via activation of Nrf2.