Histopathologic Prognostic Factors for Recurrence and Survival after Surgical Resection of Middle and Distal Bile Duct Cancer.
- Author:
Ji Young PARK
1
;
Ho Hyun KIM
;
Eun Kyu PARK
;
Jin Shick SEOUNG
;
Young Hoe HUR
;
Yang Seok KOH
;
Jung Chul KIM
;
Chol Kyoon CHO
;
Hyun Jong KIM
Author Information
1. Department of Surgery, Chonnam National University Medical School, Korea. ckcho@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Extrahepatic bile duct cancer;
Resection;
Prognostic factor;
Perineural invasion;
Lymphovascular invasion
- MeSH:
Bile;
Bile Duct Neoplasms;
Bile Ducts;
Bile Ducts, Extrahepatic;
Disease-Free Survival;
Humans;
Lymph Nodes;
Multivariate Analysis;
Neoplasm Metastasis;
Recurrence;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2010;14(3):165-172
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Surgery remains the only curative option for patients with extrahepatic bile duct cancer (EHBD Ca). But, long-term survival is typically not good because of the advanced stage of disease at the time of diagnosis and frequent disease recurrence after surgical resection. The purpose of this study was to evaluate factors that influence survival and recurrence after surgical resection of EHBD Ca. METHODS: A retrospective analysis of 113 patients who had received surgical resection for EHBD Ca between 2004 and 2009 was done. We investigated histopathological features, and survival and recurrence rates, and evaluated prognostic factors affecting survival and disease recurrence after surgical resection. RESULTS: Overall survival rates for 1, 3 and 5 years were 73.2%, 42.8%, and 36.0% respectively. In univariate analysis, prognostic factors influencing survival were histologic differentiation, T stage, lymph node (LN) metastasis, TNM stage, perineural invasion (PNI), lymphovascular invasion (LVI) and resection margin state. Among them, LN metastasis, PNI and resection margin state were found to be independent prognostic factors for overall survival in multivariate analysis. Recurrence occurred in 44 patients (48.9%) and disease-free survival rates were 50.6% at 1 year and 38.3% at 3 year. Univariate analysis revealed that histologic differentiation, T stage, LN metastasis, TNM stage, PNI and LVI were significantly associated with recurrence. In multivariate analysis, only LN metastasis was found to be a significant independent predictor of recurrence. CONCLUSION: LN metastasis, PNI and positive resection margin were significant prognostic factors affecting survival. LN metastasis was found to be a significant independent predictor of recurrence in surgical resection of EHBD Ca.
