The Effect of High-flow Nasal Cannula Oxygen for Dyspnea in Patients with Advanced Disease: Systematic Review

Sho Goya; Yasushi Nakano; Hiroaki Tsukuura; Yusuke Takagi; Hiroaki Watanabe; Yoshinobu Matsuda; Jun Kako; Yoko Kasahara; Hiroyuki Kohara; Masanori Mori; Takeo Nakayama; Takashi Yamaguchi

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The Effect of High-flow Nasal Cannula Oxygen for Dyspnea in Patients with Advanced Disease: Systematic Review

VernacularTitle:低酸素血症があり呼吸困難を有する進行性疾患患者に対する高流量鼻カニュラ酸素療法の有効性：システマティックレビュー
Author: Sho GOYA ¹ ; Yasushi NAKANO ² ; Hiroaki TSUKUURA ³ ; Yusuke TAKAGI ⁴ ; Hiroaki WATANABE ⁵ ; Yoshinobu MATSUDA ⁶ ; Jun KAKO ⁷ ; Yoko KASAHARA ⁸ ; Hiroyuki KOHARA ⁹ ; Masanori MORI ¹⁰ ; Takeo NAKAYAMA ¹¹ ; Takashi YAMAGUCHI ¹²
Author Information

1. Department of Respiratory Medicine, Kinki Central Hospital of the Mutual Aid Association of Public School Teachers
2. Department of Respiratory, Kawasaki Municipal Ida Hospital
3. Akari Home Clinic
4. Department of Palliative Medicine, Teikyo University School of Medicine Graduate School of Medicine
5. Home Palliative Care Asunaro Clinic
6. Department of Psychosomatic Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center
7. Graduate School of Medicine, Mie University
8. Department of Pharmacy, Hiroshima Prefectural Hospital
9. Department of Internal Medicine, Hatsukaichi Memorial Hospital
10. Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital
11. Department of Health Informatics, Kyoto University School of Public Health
12. Department of Palliative Medicine, Kobe University Graduate School of Medicine
Keywords: advanced disease; dyspnea; high-flow nasal canula oxygen therapy; palliative care
From:Palliative Care Research 2023;18(4):261-269
CountryJapan
Language:Japanese
Abstract: Objective: To evaluate the efficacy of high-flow nasal cannula oxygen (HFNC) for dyspnea in patients with advanced disease. Methods: A literature search was conducted using MEDLINE, Cochrane Library, EMBASE, and Ichu-shi Web. Inclusion criteria were: 1) randomized controlled trials evaluating the effect of HFNC on dyspnea; 2) aged 18 years or older with advanced disease with hypoxemia; 3) control group was conventional oxygen therapy or noninvasive positive pressure ventilation. Exclusion criteria were: 1) patients in intensive care unit, 2) weaning from ventilator. Results: Six studies (4 from database searches, and 2 from hand searches) were included. In the 2 studies evaluating short-term intervention, one showed HFNC was more efficacious, and the other conventional oxygen was more efficacious. In the 2 studies evaluating long-term interventions: one showed HFNC was more efficacious, and the other showed no significant difference. In the 2 studies evaluating the intervention during exercise, one showed HFNC was more efficacious, and the other showed no significant difference. Conclusion: HFNC may be effective for dyspnea in patients with advanced disease associated with hypoxemia.