Treatment Outcomes and Prognostic Factors in Patients with Multidrug-Resistant Tuberculosis in Korean Private Hospitals.
- Author:
Jin Kyeong PARK
1
;
Won Jung KOH
;
Deog Kyeom KIM
;
Eun Kyung KIM
;
Yu Il KIM
;
Hee Jin KIM
;
Tae Hyung KIM
;
Jae Yeol KIM
;
Moo Suk PARK
;
I Nae PARK
;
Jae Seuk PARK
;
Ki Man LEE
;
Sook Hee SONG
;
Jin Hwa LEE
;
Seung Heon LEE
;
Hyuk Pyo LEE
;
Jae Joon YIM
;
Jaemin LIM
;
Yang Jin JEGAL
;
Ki Hwan JUNG
;
Jin Won HUH
;
Jae Chol CHOI
;
Tae Sun SHIM
Author Information
- Publication Type:Original Article
- Keywords: Tuberculosis, Multidrug-Resistant; Extensively Drug-Resistant Tuberculosis; Korea; Hospitals, Private
- MeSH: Demography; Extensively Drug-Resistant Tuberculosis; HIV; Hospitals, Private; Humans; Korea; Male; Public Health; Retrospective Studies; Risk Factors; Survival Rate; Tuberculosis, Multidrug-Resistant
- From:Tuberculosis and Respiratory Diseases 2010;69(2):95-102
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75~80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. METHODS: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. RESULTS: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. CONCLUSION: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea.
