Research advances in monoclonal antibodies for treatment of drug resistance in inflammatory bowel disease

VernacularTitle:单克隆抗体治疗炎性肠病耐药的研究进展
Author: GU Jiabo
Publication Type:Journal Article
Keywords: Inflammatory bowel disease(IBD); Monoclonal antibodies; Drug resistance
From: Chinese Journal of Biologicals 2024;37(2):251-256
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease(IBD)is a complex inflammatory disease mediated by immunity that is treated with the goal of maintaining disease remission and preventing recurrence. With the deep study of the molecular mechanism of the occurrence and development of IBD,many related target molecules have been found,and the monoclonal antibodies of corresponding targets have been used to treat the disease,while the drug resistance phenomenon generated during treatment has seriously affected the treatment effect. In this paper,monoclonal antibodies such as infliximab were reviewed for the treatment of IBD resistance,with a view to understanding its possible mechanisms and exploring effective treatments and preventive measures