Functions of HIV-1 Tat and its association with diseases
10.13200/j.cnki.cjb.004166
- VernacularTitle:Ⅰ型人免疫缺陷病毒调控蛋白顺式转录激活因子的功能及其与疾病的相关性
- Author:
LI Yuanhang
- Publication Type:Journal Article
- Keywords:
Trans-activator of transcription(Tat);
Human immunodeficiency virus type 1(HIV-1);
HIV-associated neurocognitive disorder(HAND);
Acquired immune deficiency syndrome(AIDS)
- From:
Chinese Journal of Biologicals
2024;37(2):227-233
- CountryChina
- Language:Chinese
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Abstract:
Acquired immune deficiency syndrome,or AIDS,has been a major infectious disease that troubles the public health in a global scale. Human immunodeficiency virus type 1(HIV-1)is the causative reagent responsible for AIDS development. Even though the highly active anti-retroviral therapy(HAART,or the cocktail therapy)that has been widely applied could effectively suppress the infection and replication of HIV-1,the infected people suffer from other related diseases,such as the HIV-associated neurocognitive disorder(HAND). This paper mainly focused on the function of an important regulatory protein of HIV-1,trans-activator of transcription(Tat),and its correlation with HIV-1 replication and HAND development,so as to clarify the importance of developing anti-AIDS drugs targeting Tat protein
