Bidirectional casual effects between periodontitis and Sjögren's syndrome: a Mendelian randomization study
10.12016/j.issn.2096-1456.2024.03.007
- Author:
XIE Peili
1
,
2
,
3
,
4
;
GUO Chenmiao
1
,
2
,
3
,
4
;
YU Ting
1
,
2
,
3
,
4
Author Information
1. School and Hospital of Stomatology &
2. Guangdong Engineering Research Center of Oral Restoration and Reconstruction &
3. Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine &
4. Guangzhou Medical University
- Publication Type:Journal Article
- Keywords:
periodontitis / Sjögren's syndrome / Mendelian randomization / genome-wide association study / causal association / bidirectional casual association / confounder / inverse variance-weighted
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(3):209-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the bidirectional association between periodontitis and Sjögren's syndrome using the Mendelian randomization (MR) method.
Methods:Genome-wide association study (GWAS) data of periodontitis (N = 45 563) and Sjögren's syndrome (N = 214 435) were selected to meet the requirements of the same ethnicity and different regions. Inverse variance-weighted (IVW), MR-Egger, and weighted median (WM) tests were used to evaluate the causal effect. Cochran's Q statistics, MR-Egger intercept, MR-PRESSO and leave-one-out analysis were used as sensitivity analyses to assess the stability and reliability of the results.
Results:After screening, the GWAS data of Sjögren's syndrome were based on the Finnish region, and the periodontitis GWAS data were based on the UK region, both of which originated from European ancestry. Using IVW (OR = 1.017, 95% CI = 0.956-1.082), MR-Egger (OR = 0.985, 95% CI= 0.956-1.082), and WM (OR =1.021, 95% CI = 0.948-1.099), no causal effect of Sjögren's syndrome on periodontitis was found using any of the three methods. Conversely, no causal effect of periodontitis on Sjögren's syndrome was found (IVW, OR = 1.024, 95% CI = 0.852-1.230; MR-Egger, OR = 0.978, 95% CI = 0.789-1.212; WM, OR = 1.024, 95% CI = 0.846-1.260). The sensitivity analyses indicated that the results were stable and reliable. Cochran's Q test and MR-PRESSO revealed that there was no significant heterogeneity among the instrumental variables, which included single nucleotide polymorphisms (SNPs). The intercept of MR-Egger regression indicated no pleiotropy in the included SNPs. No individual SNP was found that significantly affected the results using the leave-one-out method.
Conclusion:This study does not support a bidirectional causal effect between periodontitis and Sjögren's syndrome.
- Full text:牙周炎与干燥综合征的因果关系 一项孟德尔随机化研究.pdf
