Study on the treatment of cerebral infarction with Chinese medicine Shenmajingfu granule by network pharmacology
10.12206/j.issn.2097-2024.202303013
- VernacularTitle:中药复方参麻颈复颗粒治疗脑梗死的网络药理学研究
- Author:
Yi XU
1
;
Ruihua HE
1
;
Jin HUANG
1
Author Information
1. Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
- Keywords:
Shenmajingfu granules;
cerebral infarction;
network pharmacology
- From:
Journal of Pharmaceutical Practice and Service
2024;42(2):66-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the material basis and mechanism of the Chinese medicine Shenmajingfu granules in the treatment of cerebral infarction. Methods The potential active ingredients and targets of Shenmajingfu granules were retrieved through TCMSP, ETCM database and TCM Database. The related target genes of cerebral infarction were searched from OMIM database. The common targets of Shenmajingfu granules and cerebral infarction were obtained by the intersection method. Cytoscape was used to construct active components of Shenmajingfu granules-targets network. Protein-protein interaction network was constructed by STRING software. DAVID database was used for GO and KEGG enrichment analysis. Results The 183 potential active ingredients of Shenmajingfu granules were screened out. 1785 potential targets were screened in the TCMSP database, including 30 targets related to cerebral infarction. These target genes were mainly involved in the inflammatory response and apoptosis process, involving the TNF signaling pathway, HIF-1 signaling pathway and NF-κB signaling pathway. Conclusion The therapeutic effect of Shenmajingfu granules on cerebral infarction may be related to the regulation of inflammatory response, improvement of impaired neurological function and protection of cerebral ischemia-reperfusion injury.
