A Case of Rosai-Dorfman Disease with Highly Elevated Serum Ferritin.
10.3343/alm.2012.32.2.158
- Author:
Sung Yoon REW
1
;
Hee Chang JANG
;
Kyung Hwa PARK
;
Jae Sook AHN
;
Ga Eon KIM
;
Yoo Duk CHOI
;
Sook In JUNG
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. haroc153@naver.com
- Publication Type:Case Reports
- Keywords:
Ferritin;
Fever of unknown origin;
Sinus histiocytosis with massive lymphadenopathy;
Rosai-Dorfman disease
- MeSH:
Adult;
C-Reactive Protein/analysis;
Female;
Ferritins/*blood;
Histiocytosis, Sinus/blood/*diagnosis/pathology;
Humans;
L-Lactate Dehydrogenase/blood;
Lymph Nodes/pathology;
Positron-Emission Tomography and Computed Tomography
- From:Annals of Laboratory Medicine
2012;32(2):158-161
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful diagnostic markers for this disorder prior to histological confirmation. High elevation of serum ferritin is known to be a useful diagnostic marker for various hematologic diseases, including hemophagocytic lymphohistiocytosis and lymphoma. Here, we report a case of fever of unknown origin that presented along with highly elevated serum ferritin (5,780 ng/mL), and was finally diagnosed as Rosai-Dorfman disease by lymph node biopsy.
