R-CHOP and consolidation radiotherapy for limited-stage and low-IPI high-grade b-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: A single-center case series and review of literature
https://doi.org/10.47895/amp.vi0.8611
- Author:
Joseff Karl U. Fernandez
1
;
Michael D. San Juan
1
;
Edilberto Joaquin V. Fragante, Jr.
2
;
Billionario Januario Antonio D. Veloso, Jr.
3
;
Timothy Carl F. Uy
3
;
Michelle Regina L. Castillo
2
;
Benedict Mihangel P. Crisostomo
2
Author Information
1. Division of Medical Oncology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila
2. Division of Radiation Oncology, Department of Radiology, Philippine General Hospital, University of the Philippines Manila
3. Department of Laboratories, Philippine General Hospital, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
R-CHOP;
High-Grade B-Cell Lymphoma;
HGBCL;
Low-IPI;
MYC and BCL2 translocation;
Consolidation radiotherapy
- From:
Acta Medica Philippina
2024;58(Early Access 2024):1-11
- CountryPhilippines
- Language:English
-
Abstract:
High-Grade B-Cell Lymphoma (HGBCL) with gene rearrangements in MYC and BCL2 and/or BCL6 is an aggressive malignancy usually presenting in advanced stages. Current recommendations suggest the use of regimens more intensive than R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, prednisone), which are based on retrospective studies and single-arm prospective trials that included patients who are mostly in the advanced stage, and did not receive consolidation radiotherapy.
The optimal approach and treatment of HGBCL, whether limited-stage (LS) or advanced-stage, remains to be
determined. Here we describe the promising outcomes of three patients with LS and low IPI HGBCL with the use of R-CHOP as induction chemotherapy regimen, which was followed by consolidation radiotherapy.
Three women, 54-, 60-, and 64-years of age diagnosed to have HGBCL with MYC, and BCL2 and/or BCL6 rearrangements, with Ann Arbor stages I-IIE were included in this case series. All three patients had complete metabolic response to 6 cycles of R-CHOP and was subsequently treated with consolidation involved site radiotherapy (ISRT; total dose 30-36 Gy). Chemotherapy and radiotherapy were tolerated very well. All patients remain to be in remission, with the longest being at 23 months.
Outcomes of patients with HGBCL generally remain to be poor, but this may not be the case for patients with
limited-stage disease and favorable clinicopathologic risk profile. Nevertheless, the treatment of HGBCL is currently evolving and more studies are needed to determine the ideal approach and preferred chemotherapy regimen. Also, more studies are needed to elucidate the potential role of consolidation radiotherapy in patients with limited-stage HGBCL to improve survival outcomes. Findings of this case series suggest that patients with LS HGBCL may still derive benefit from R-CHOP followed by consolidation ISRT, but prospective trials are needed to confirm this.
- Full text:early access 1.pdf
