Advances in research on pathological mechanism and therapeutic drugs for coronavirus disease 2019

Qixia Zhu; Qingguang Liu; Hongxia LI

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Advances in research on pathological mechanism and therapeutic drugs for coronavirus disease 2019

VernacularTitle:新型冠状病毒肺炎的病理机制及治疗药物研究进展
Author: Qixia ZHU ¹ ; Qingguang LIU ² ; Hongxia LI ^{1
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Author Information

1. Department of Medical Administration, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
2. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
3. Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: coronavirus disease 2019; severe acuterespiratory syndrome coronavirus 2; pathological mechanism; therapeutic drug
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(1):103-107
CountryChina
Language:Chinese
Abstract: Coronavirus disease 2019 has become a pandemic. The transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is strong, and the population is generally susceptible. The virus enters target cells via angiotensin-converting enzyme 2 as a cellular receptor.Spike protein is activated by serine protease TMPRSS2. The virus can cause damage to multiple organs, and there are currently no specific drugs for this virus. However, several assessments and studies have been carried out. At present, the epidemic situation in China has been effectively controlled. However,the number of infections abroad has increased rapidly. Therefore, the epidemic situation in foreign countries is still very serious. The global epidemic prevention and control work is facing huge challenges. In order to effectively prevent and treat coronavirus disease 2019, this article reviews the etiology, pathological mechanism, pathological manifestations, and development of therapeutic drugs for coronavirus disease 2019.