Expression and roles of NUPR1 in cholangiocarcinoma cells.
- Author:
Ki Sun KIM
1
;
Du Il JIN
;
Sik YOON
;
Sun Yong BAEK
;
Bong Seon KIM
;
Sae Ock OH
Author Information
- Publication Type:Original Article
- Keywords: NUPR1; Cholangiocarcinoma; Migration; Invasion; Proliferation
- MeSH: Cell Line; Cholangiocarcinoma; Humans; Immunohistochemistry; Nuclear Proteins; RNA, Small Interfering
- From:Anatomy & Cell Biology 2012;45(1):17-25
- CountryRepublic of Korea
- Language:English
- Abstract: Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
