Association of gestational diabetes mellitus and blood glucose level during the second trimester with neonatal birth weight: A study based on birth cohort

Doudou Zhao; Li Shan; Yang MI; Shaonong Dang; Wenhao Shi; Pengfei QU

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Association of gestational diabetes mellitus and blood glucose level during the second trimester with neonatal birth weight: A study based on birth cohort

VernacularTitle:妊娠期糖尿病及孕中期血糖水平与新生儿出生体质量的关联研究：基于出生人口队列
Author: Doudou ZHAO ¹ ; Li SHAN ^{2
,

3} ; Yang MI ⁴ ; Shaonong DANG ⁵ ; Wenhao SHI ^{1
,

6} ; Pengfei QU ¹
Author Information

1. Department of Translational Medicine Center, Northwest Women’s and Children’s Hospital, Xi’an 710061
2. Department III of Gynecology, Northwest Women’s and Children’s Hospital
3. Xi’an 710061
4. Department of the second Obstetrics, Northwest Women’s and Children’s Hospital, Xi’an 710061
5. Department of Epidemiology and Biostatistics, School of Public Health of Xi’an Jiaotong University Health Science Center, Xi’an 710061
6. Department of Reproductive Center, Northwest Women’s and Children’s Hospital, Xi’an 710061, China
Publication Type:Journal Article
Keywords: gestational diabetes mellitus; birth weight of the newborn; fasting plasma glucose
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(2):311-316
CountryChina
Language:Chinese
Abstract: 【Objective】 To explore the association of gestational diabetes mellitus (GDM) and blood glucose level with birth weight of the newborns in Northwest China. 【Methods】 Pregnant women in their first trimester who joined the birth cohort of Northwest Women and Children’s Hospital from July 2018 to July 2019 were consecutively enrolled. We collected their basic demographic characteristics, lifestyle behavior and other data. We followed up the results of the OGTT test and pregnancy outcomes. The generalized linear model was used to analyze the effects of GDM and blood glucose levels on the birth weight of newborns. 【Results】 A total of 2 422 subjects were included in this study, and 656 (27.09%) pregnant women had GDM during pregnancy. Pregnant women with GDM increased the birth weight (β=50.00, 95% CI: 17.48-82.51), Z-value (β=0.11, 95% CI: 0.03-0.19) and Z Centile value (β=3.22, 95% CI: 0.88-5.55), and increased the risk of macrosomia (OR=1.54, 95% CI: 1.04-2.28). Abnormal FPG value during the second trimester would increase the risk of macrosomia and LGA. With the increase of OGTT blood glucose value in the second trimester, the birth weight value and the incidence of macrosomia and LGA showed an upward trend. 【Conclusion】 Pregnancy in women with GDM might increase the birth weight of newborns and the risk of macrosomia, especially FPG. We should vigorously control the blood glucose level of GDM patients to promote the health of mothers and infants.